Publications

Journal A foundational model encodes deep phenotyping data and enables diverse downstream applications. npj Digital Medicine, 2026.
In press GWAS meta-analyses with a new Chinese population expand the genetic architecture and improve ancestry-specific genetic risk prediction of chronic obstructive pulmonary disease. Genomics Proteomics and Bioinformatics, 2026.
Under review Proteo-metabolomic insights into the progression of COPD and lung function decline. Respiratory Research, 2026.
Journal Multi-omics Mendelian Randomization Identifies SERPING1 as a COPD Modulator. Signal Transduction and Targeted Therapy, 2025.
Journal Model confrontation and collaboration: a debate intelligence framework for enhancing medical reasoning in large language models. Cell Reports Medicine, 2025.
Journal Genetic determinants of gene expression noise and its role in complex trait variation. Cell Reports, 2025.
In revision Educator-LLM collaboration strategies for discharge education in hematopoietic stem cell transplantation: a randomized controlled trial of real-time prompting. NEJM AI, 2026.
Journal Deep multi-omics profiling reveals three distinct molecular subtypes of chronic obstructive pulmonary disease in a unique biomass-exposed Chinese population. Med, 2025.
Submitted Cough, sputum, and CD164: novel risk factors/biomarkers for COPD and lung function decline. Respiratory Research, 2026.
Under review A mediation-informed causal pathway powers a large language model for individualized health advisory. Nature Aging, 2026.